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Different pathways contribute to the turnover of connexins, the main structural components of gap junctions (GJs). The cellular pool of connexins targeted to each pathway and the functional consequences of degradation through these degradative pathways are unknown. In this work, we focused on the contribution of macroautophagy to connexin degradation. Using(More)
The plasma membrane contributes to the formation of autophagosomes, the double-membrane vesicles that sequester cytosolic cargo and deliver it to lysosomes for degradation during autophagy. In this study, we have identified a regulatory role for connexins (Cx), the main components of plasma membrane gap junctions, in autophagosome formation. We have found(More)
The plasma membrane contributes to formation of autophagosomes, the double-membrane vesicles that sequester cytosolic cargo and deliver it to lysosomes for degradation during autophagy. In this study, we have identified a regulatory role for connexins (Cx), main components of plasma membrane gap junctions, in autophagosome formation. We have found that(More)
Different pathways contribute to the turnover of connexins, the main structural components of gap junctions (GJ). The cellular pool of connexins targeted to each pathway and the functional consequences of degradation through these degradative pathways remain unknown. In this work, we have focused on the contribution of macroautophagy to connexin(More)
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