Andrea Visconti

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BACKGROUND The pleiotropic effects of riluzole may antagonize common mechanisms underlying chronic cerebellar ataxia, a debilitating and untreatable consequence of various diseases. METHODS In a randomized, double-blind, placebo-controlled pilot trial, 40 patients presenting with cerebellar ataxias of different etiologies were randomly assigned to(More)
Previous studies reported an association with multiple sclerosis (MS) of distinct HLA-class I markers, namely HLA-A*02, HLA-Cw*05 and MOG-142L. In this work, we tested the association with MS of A*02 and Cw*05 in 1273 Italian MS patients and 1075 matched controls, which were previously analyzed for MOG-142, and explored the relationship among these three(More)
The roles of plasmacytoid dendritic cells (pDCs) and their response to interferon (IFN)-beta therapy in multiple sclerosis (MS) patients are poorly understood. We identified pDC accumulation in white matter lesions and leptomeninges of MS brains and abundant expression of the Type I IFN-induced protein MxA, mainly in perivascular CD3+ lymphocytes in(More)
The role of some chemical elements in neurodegeneration was suggested by various authors. To obtain a profile of chemical elements and oxidative status in complex neurological diseases, an unbiased "omics" approach, i.e., quantification of 26 elements and oxidative stress parameters (serum oxidative status (SOS) and serum anti-oxidant capacity (SAC)),(More)
BACKGROUND Metals are suspected of being involved in the pathogenesis of various neurologic diseases. We previously found a complex imbalance in serum chemical elements and oxidative status in patients with clinically definite multiple sclerosis (CDMS). OBJECTIVE To understand whether this imbalance affects people with clinically isolated syndrome (CIS)(More)
In this paper, we discuss the design and engineering of a biologically-inspired, host-based intrusion detection system to protect computer networks. To this end, we have implemented an Artificial Immune System (AIS) that mimics the behavior of the biological adaptive immune system. The proposed AIS, consists of a number of running artificial white blood(More)
Implementation of routing protocols in mobile ad-hoc networks relies on efficient node cooperation. However, node misbehavior is a common phenomenon, thus, ad-hoc networks are subject to packet dropping, packet modification, packet misrouting, selfish node behavior, and so on. In this paper, a biologically-inspired type-2 fuzzy set recognition algorithm for(More)