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Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
Background The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is aExpand
Trypanosoma cruzi chemical proteomics using immobilized benznidazole.
The untargeted search for Bzn binding partners allowed for proteins that could be related to drug reductive activation and/or resistance mechanisms to be encountered, including the aldo-ketoreductase family member TcAKR. Expand
Trypanosoma cruzi TBP shows preference for C/G-rich DNA sequences in vitro.
Results of Systematic Evolution of Ligands by Exponential Enrichment (SELEX) experiments show that Trypanosoma cruzi TBP has an in vitro binding preference for G-rich sequences, which suggests that this factor could play a role in locating the initiation complex in the right TSS, probably by "sensing" the G-content on the strand to be transcribed. Expand
Old Yellow Enzyme from Trypanosoma cruzi Exhibits In Vivo Prostaglandin F2α Synthase Activity and Has a Key Role in Parasite Infection and Drug Susceptibility
A prokaryotic evolutionary origin is proposed for TcOYE, and in vitro and in vivo experiments are used to show that T. cruzi prostaglandin F2α synthase plays an important role in modulating the infection process. Expand
Bestatin Induces Specific Changes in Trypanosoma cruzi Dipeptide Pool
After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases. Expand
Characterization of TcHMGB, a high mobility group B family member protein from Trypanosoma cruzi.
Immunofluorescence and western blot assays showed that TcHMGB is a nuclear protein expressed in all life cycle stages, however, protein levels seem to vary throughout the life cycle, which may be related to previously described changes in heterochromatin distribution and transcription rates. Expand
Description of Dioszegia patagonica sp. nov., a novel carotenogenic yeast isolated from cold environments.
During a survey of carotenogenic yeasts from cold and oligotrophic environments in Patagonia, several yeasts of the genus Dioszegia were detected, including three strains that could not be assigned to any known taxa. Expand
Novel yeast taxa from the cold: description of Cryolevonia giraudoae sp. nov. and Camptobasidium gelus sp. nov.
Twenty-one psychrophilic yeast isolates related to the Camptobasidiaceae family in the Microbotryomycetes class were obtained from ice collected from cold environments worldwide. A new psychrophilicExpand
Biotechnologically Relevant Yeasts from Patagonian Natural Environments
The present work represents an overview of the findings related to biotechnologically relevant yeasts from Patagonian natural environments. Expand