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8528 There have been reports of osteonecrosis of the jaw (ONJ) in patients (pts) with metastatic bone disease (MBD) treated with IV bisphosphonates (IVBP). To estimate the frequency and identify risk factors for ONJ we performed a retrospective analysis of pts treated with IVBP. The cohort included 4019 patients identified through the MDACC pharmacy(More)
INTRODUCTION Osteonecrosis of the jaw (ONJ) has been reported in patients treated with bisphosphonates. The incidence and risk factors associated with this disorder have not been clearly defined. MATERIALS AND METHODS We conducted a retrospective analysis of 4019 patients treated with intravenous bisphosphonates between 1996 and 2004. Our goals were to(More)
Distribution in rat tissues of citalopram, a potent and specific inhibitor of neuronal 5-HT uptake was uneven. The blood serum level of the drug did not reflect its distribution in the brain tissue and in the spinal cord. Prolonged administration of citalopram enhanced its blood serum, brain and spinal cord AUC values and slowed down its elimination from(More)
Results of surgery in oesophageal cancer are still disappointing. The only possible solution is to search actively for early cancer in nonsymptomatic person. The group of patients with Barrett's oesophagus or after lye ingestion was included in the endoscopical screening programme. In order to improve our results and increase sensitivity we have employed(More)
Pharmacokinetics of imipramine (IMI) and its active metabolite, desipramine (DMI) was studied in rats after administration of a single dose of 10 mg/kg IMI, or after chronic administration of this dose once or twice a day for 14 days. The elimination curves of IMI and DMI from the blood and brain show that both the whole body and the brain behave as(More)
BACKGROUND In this study, we compare 2 treatment options and determine cost-effectiveness and cost-utility. METHODS We carried out a decision analysis populated with data from patients with brain metastasis in a concurrent trial randomized to either stereotactic radiosurgery (SRS) and observation or SRS and whole brain radiation therapy. Outcomes included(More)
Our objective was to assess the prevalence of use of different classes of antidepressants, prescribing patterns, and determinants of exposure to specific types of antidepressants and resource utilization at a comprehensive cancer center from 2001 to 2006. Data were collected from the institution's outpatient pharmacy database and cross-referenced with the(More)
6132 Background: Antidepressant (AD) therapy may be initiated in cancer patients for affective or anxiety disorders, or management of symptoms. Practice patterns vary, and prescribing trends are poorly understood. METHODS Retrospective cohort study using outpatient prescribing data and routine clinical data available through the computerized data system(More)
This research compares the effects, in mice and rats, of desmethylclomipramine (DCLOM) and clomipramine (CLOM). DCLOM antagonized the hypothermia induced in mice by reserpine or apomorphine to a much greater extent than CLOM. Reserpine ptosis in mice was depressed by DCLOM only. Similarly, only DCLOM was effective in the behavioral despair test in rats.(More)
OBJECTIVE The purpose is to evaluate antidepressant compliance in a cancer population at a tertiary cancer center and to determine if there are covariates of importance in predicting the level of compliance in the study population. METHODS Patients who received at least three prescriptions covering parts of each month for a continuous 6-month period with(More)