Andrea Sorrentino

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RATIONALE Hypoxia favors stem cell quiescence, whereas normoxia is required for stem cell activation, but whether cardiac stem cell (CSC) function is regulated by the hypoxic/normoxic state of the cell is currently unknown. OBJECTIVE A balance between hypoxic and normoxic CSCs may be present in the young heart, although this homeostatic control may be(More)
BACKGROUND Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the adult heart experimentally. Moreover, whether these Ca(2+) release channels are present and play a critical role in human cardiomyocytes remains to be defined. IP3Rs may be activated after Gαq-protein-coupled receptor stimulation, affecting Ca(2+) cycling,(More)
BACKGROUND Aging negatively impacts on the function of resident human cardiac progenitor cells (hCPCs). Effective regeneration of the injured heart requires mobilization of hCPCs to the sites of damage. In the young heart, signaling by the guidance receptor EphA2 in response to the ephrin A1 ligand promotes hCPC motility and improves cardiac recovery after(More)
The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes are important determinants of the diastolic characteristics of the myocardium, independently from changes in structural composition(More)
Studies of myocardial aging are complex and the mechanisms involved in the deterioration of ventricular performance and decreased functional reserve of the old heart remain to be properly defined. We have studied a colony of beagle dogs from 3 to 14 yr of age kept under a highly regulated environment to define the effects of aging on the myocardium.(More)
BACKGROUND Diabetes is associated with prolongation of the QT interval of the electrocardiogram and enhanced dispersion of ventricular repolarization, factors that, together with atherosclerosis and myocardial ischemia, may promote the occurrence of electrical disorders. Thus, we tested the possibility that alterations in transmembrane ionic currents reduce(More)
1 De Dept pt p s s of f A Ane est st sthe h sia and Medicine, and Divisi sion on on of Cardiovascular ar Me M M dicine, Brigham and Wo Wo Wom me men' n' 's s s H H Hosp sp pit it ita al, Harvard Medical School; 2 2 2 Ca Ca C r rdiovascular I In ns n titu tute te te, , Beth Israel Deaconess Me Me Medical Ce Ce ent nt nter er er, Ha Ha arv rv rvar ar ard d d(More)
We thank Drs Heidrich and colleagues for their comments on our study discussing the role of inositol 1,4,5-trisphosphate receptors (IP3Rs) in ventricular myocytes. We documented that IP3Rs are present and operative in the rodent and human ventricular myocardium and that stimulation of Gαq-protein-coupled receptors promotes IP3R-mediated Ca release. This(More)
Diabetes and other metabolic conditions characterized by elevated blood glucose constitute important risk factors for cardiovascular disease. Hyperglycemia targets myocardial cells rendering ineffective mechanical properties of the heart, but cellular alterations dictating the progressive deterioration of cardiac function with metabolic disorders remain to(More)
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