Self-emulsifying oil/surfactant mixtures can be incorporated into pellets that have the advantages of the oral administration of both microemulsions and a multiple-unit dosage form. The purpose of this work was to study the effects of surfactant hydrophilic–lipophilic balance (HLB) and oil/surfactant ratio on the formation and properties of self-emulsifying… (More)
Specific ion effects on the Brownian molecular motion of BSA protein under physiological conditions are investigated. New useful insights into Hofmeister phenomena related to electrolyte-protein interactions are presented.
We considered the Inverse Compton Scattering (ICS) of charged particles onto photons whose distribution is a Black Body Radiation (BBR) deriving the exact energy and angular differential distribution in the general case and in its most useful expansions. These results can be successfully applied in high energy accelerators experiments to evaluate the ICS… (More)
Most of the known literature on Inverse Compton Scattering (ICS) is based on earliest theoretical attempts and later approximations led by F.C.Jones and J.B.Blumenthal. We found an independent and more general analytical procedure which provide both relativistic and ultrarelativistic limits for ICS. These new analytical expressions can be derived in a… (More)
The Precessing Gamma Jets (GJ) in binary systems located in extended or evaporating galactic halo should be the source of GRB. The GJ are born by Inverse Compton Scattering (ICS) of thermal photons (optical, infrared,...) onto (power law) electron jets (from GeV energies and above) produced by spinning pulsars or black holes. The thermal photons are emitted… (More)
Cannabinoids, endogenous and exogenously administered, are known to positively regulate food intake and energy balance. Since CB1 receptor antagonists reduce food intake and antagonize overweight, we developed a new CB1 receptor antagonist in an attempt to identify a compound with potential application in overeating disorders. The newly developed SM-11… (More)
Self-emulsifying pellets were prepared using microcrystalline cellulose, emulsions of caprylic/capric triglyceride, and three Cremophors (ELP, RH40, and RH60) at 1.5 and 2.3 weight ratios, and two drugs (furosemide and propranolol) of different lipophilicity. Droplet size, zeta potential (ζ) and viscosity of emulsions, and pellet size, shape, friability,… (More)