Andrea Saggini

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Microglia derive from mononuclear myeloid progenitors and are a major glial complement of the central nervous system. When microglia are activated they secrete inflammatory cytokines and toxic mediators which amplify the inflammatory response. In addition, the microglia inflammatory products are implicated in the neuronal destruction usually observed in(More)
Psoriasis vulgaris (PV) is a cutaneous inflammatory disorder stemming from abnormal, persistent activation of the interleukin- (IL-)23/Th17 axis. Pustular psoriasis (PP) is a clinicopathological variant of psoriasis, histopathologically defined by the predominance of intraepidermal collections of neutrophils. Although PP pathogenesis is thought to largely(More)
Exome sequencing Genomic DNA was isolated using the Qiagen Blood/Tissue kit (Qiagen, Valencia, CA). Exome capture was performed with the Agilent SureSelect All-Exon v2 kit, and 100 bp paired-end library reads were generated on Illumina HiSeq 2000 to a 50-fold target average depth of coverage. Alignment of reads to the human genome was performed with(More)
Regular training programs are a concrete means to prevent and/or reduce functional decline due to aging. A multisensory training approach seems to obtain better results in the elderly with regard to both balance and quality of life. Forty subjects (age 65+/-10 years, height 165+/-4 cm, weight 73.0+/-4.6 kg) were randomized into two groups (GrHu and GrCl).(More)
Psoriasis is a chronic and immunomediated skin disease characterized by erythematous scaly plaques. Psoriasis affects approximately 1% to 3% of the Caucasian population. Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that plays a critical role in the pathogenesis of psoriasis. Infliximab is an anti-TNF-α drug widely used for the treatment(More)
Plastic surgery offers a quite unique window on abrupt and permanent modifications of a human's body schema. Its impact is comparable to amputations or other severe injuries, with the evident advantage from the experimenter's (and patient's) point of view that it is planned, allowing longitudinal studies and quantification of the weight(More)
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