Andrea S Henden

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Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow transplantation whereby transplanted naive and marrow-derived T cells damage recipient tissue through similar mechanisms to those that allow destruction of malignant cells, the therapeutic intent of bone marrow transplantation. The manifestations and severity of GVHD are highly(More)
A 27-old-year old man presented with a 2-week history of increasing lymphadenopathy in his groin and neck. He also had marked hepatosplenomegaly. His blood count showed a haemoglobin concentration of 161 g/l, white cell count 37Æ1 · 10/l and platelet count 45 · 10/l. His blood film was leucoerythroblastic. A bone marrow aspirate (top) showed a marked(More)
To the Editor: We describe the presentation of a 45-yr-old male to our hospital emergency department with symptoms of increasing abdominal pain, shortness of breath and night sweats that had been present for several weeks. In addition the patient had noted a slowly growing left sided abdominal mass that had been present for 8 months. Clinical examination(More)
Donor T-cell-derived interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), however protective roles remain unclear. Using multiple cytokine and cytokine receptor subunit knockout mice, we demonstrate that stem cell transplant recipients lacking the ability to generate or signal IL-17 develop intestinal hyper-acute(More)
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