Andrea S Cornford

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CONTEXT The very low GH concentration in obesity is commonly attributed to high body fat mass; however, the influence of overeating on GH secretion is not clear. OBJECTIVE The aim of the study was to examine the effects of 2 wk of overeating on changes in GH secretion. SETTING Subjects were admitted to the hospital and stayed within the Michigan(More)
CONTEXT It is unclear whether the pattern of GH delivery to peripheral tissues has important effects. OBJECTIVE The aim of the study was to compare the effects of pulsatile vs. continuous administration of GH upon metabolic and IGF-I parameters in obese subjects. SETTING The study was conducted at the General Clinical Research Center at the University(More)
Previously, we reported that overeating for only a few days markedly suppressed the secretion of growth hormone (GH). The purpose of the present study was to determine the role of this reduction in GH concentration on key metabolic adaptations that occur during 2 wk of overeating. Nine nonobese, healthy adults were admitted to the hospital for 2 wk, during(More)
Prolonged overeating and the resultant weight gain are clearly linked with the development of insulin resistance and other cardiometabolic abnormalities, but adaptations that occur after relatively short periods of overeating are not completely understood. The purpose of this study was to characterize metabolic adaptations that may accompany the development(More)
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