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BACKGROUND Mechanisms involving oxidative stress and inflammation have been proposed to explain associations of ambient air pollution with cardiovascular morbidity and mortality. Experimental evidence suggests that organic components and ultrafine particles (UFP) are important. METHODS We conducted a panel study of 60 elderly subjects with coronary artery(More)
BACKGROUND Biomarkers of systemic inflammation have been associated with risk of cardiovascular morbidity and mortality. OBJECTIVES We aimed to clarify associations of particulate matter (PM) air pollution with systemic inflammation using models based on size-fractionated PM mass and markers of primary and secondary aerosols. METHODS We followed a panel(More)
BACKGROUND Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine particles <or= 0.25 microm in aerodynamic(More)
BACKGROUND Air pollutants have not been associated with ambulatory electrocardiographic evidence of ST-segment depression ≥ 1 mm (probable cardiac ischemia). We previously found that markers of primary (combustion-related) organic aerosols and gases were positively associated with circulating biomarkers of inflammation and ambulatory blood pressure in the(More)
Sampling and handling artifacts can bias filter-based measurements of particulate organic carbon (OC). Several measurement-based methods for OC artifact reduction and/or estimation are currently used in research-grade field studies. OC frequently is not artifact-corrected in large routine sampling networks (e.g., U.S. Environmental Protection Agency (EPA)'s(More)
Disclaimer The contents of this report reflect the views of the authors, who are responsible for the facts and the accuracy of the information presented herein. The document is disseminated under the sponsorship of Abstract The primary objective of this project is to develop an improved understanding of the factors affecting the toxicology of particulate(More)
Dedication To my parents for their love; they are the reason I am here. ii Acknowledgments This thesis was done under the guidance of my graduate advisor, Professor Costantinos Sioutas. I express my sincere gratitude and appreciation to him for giving me the opportunity to work in his research group and his expert advice and encouragement during the whole(More)
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