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BACKGROUND Mechanisms involving oxidative stress and inflammation have been proposed to explain associations of ambient air pollution with cardiovascular morbidity and mortality. Experimental evidence suggests that organic components and ultrafine particles (UFP) are important. METHODS We conducted a panel study of 60 elderly subjects with coronary artery(More)
BACKGROUND Biomarkers of systemic inflammation have been associated with risk of cardiovascular morbidity and mortality. OBJECTIVES We aimed to clarify associations of particulate matter (PM) air pollution with systemic inflammation using models based on size-fractionated PM mass and markers of primary and secondary aerosols. METHODS We followed a panel(More)
A photo-electric aerosol sensor, a diffusion charger, an Aethalometer, and a continuous particle counter were used along with other real-time instruments to characterize the particle-bound polycyclic aromatic hydrocarbon (p-PAH) content, and the physi-cal/chemical characteristics of aerosols collected a) in Wilmington (CA) near the Los 5 Angeles port and(More)
Measurements of organic carbon compounds in both the gas and particle phases measured upwind, over and downwind of North America are synthesized to examine the total observed organic carbon (TOOC) over this region. These include measurements made aboard the NOAA WP-3 and BAe-146 aircraft, the NOAA research vessel Ronald 5 H. Brown, and at the Thompson Farm(More)
BACKGROUND Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine particles <or= 0.25 microm in aerodynamic(More)
BACKGROUND Air pollutants have not been associated with ambulatory electrocardiographic evidence of ST-segment depression ≥ 1 mm (probable cardiac ischemia). We previously found that markers of primary (combustion-related) organic aerosols and gases were positively associated with circulating biomarkers of inflammation and ambulatory blood pressure in the(More)
Sampling and handling artifacts can bias filter-based measurements of particulate organic carbon (OC). Several measurement-based methods for OC artifact reduction and/or estimation are currently used in research-grade field studies. OC frequently is not artifact-corrected in large routine sampling networks (e.g., U.S. Environmental Protection Agency (EPA)'s(More)
ii Disclaimer The statements and conclusions in this report are those of the University and not necessarily those of the California Air Resources Board. The mention of commercial products, their source, or their use in connection with material reported herein is not construed as actual or implied endorsement of such products. Acknowledgements We thank our(More)
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