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  • Stefano Fiorucci, Elisabetta Antonelli, +6 authors Antonio Morelli
  • Biology, Medicine
  • Gastroenterology
  • 2004 (First Publication: 1 November 2004)
  • BACKGROUND AND AIMS The farnesoid X receptor (FXR) is an endogenous sensor for bile acids and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene expression. The aim of thisContinue Reading
  • Eleonora Distrutti, Luca Sediari, +8 authors Stefano Fiorucci
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2006 (First Publication: 1 January 2006)
  • Hydrogen sulfide (H2S) functions as a neuromodulator, but whether it modulates visceral perception and pain is unknown. Cystathionineβ -synthase (CBS) and cystathionine-γ-lyase (CSE) mediateContinue Reading
  • Stefano Fiorucci, Stefano Orlandi, +6 authors John Longstreet Wallace
  • Medicine
  • British journal of pharmacology
  • 2007 (First Publication: 29 January 2009)
  • BACKGROUND AND PURPOSE Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease. Hydrogen sulphide has been shown to beContinue Reading
  • Stefano Fiorucci, Giovanni Rizzo, +6 authors Roberto Pellicciari
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2005 (First Publication: 1 October 2005)
  • The nuclear receptors farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)γ exert counter-regulatory effects on hepatic stellate cells (HSCs) and protect against liverContinue Reading
  • Stefano Fiorucci, Andrea Mencarelli, Giuseppe Palladino, Sabrina Cipriani
  • Biology, Medicine
  • Trends in pharmacological sciences
  • 2009 (First Publication: 1 November 2009)
  • Bile acids are a family of steroid molecules generated in the liver by cholesterol oxidation. In addition to their role in nutrient absorption, bile acids are signaling molecules that exert genomicContinue Reading