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Characterization of p53 Wild-Type and Null Isogenic Colorectal Cancer Cell Lines Resistant to 5-Fluorouracil, Oxaliplatin, and Irinotecan
To elucidate mechanisms of resistance to chemotherapies currently used in the first-line treatment of advanced colorectal cancer, we have developed a panel of HCT116 p53 wild-type (p53+/+) and nullExpand
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The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells
Polyamines have been shown to play a role in the growth and survival of several solid tumors, including colorectal cancer. We identified the polyamine catabolic enzyme spermidine/spermineExpand
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Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer.
DNA microarray analysis was used to analyze the transcriptional profile of HCT116 colorectal cancer cells that were treated with 5-fluorouracil (5-FU) or oxaliplatin and selected for resistance toExpand
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Prostate-derived factor—a novel inhibitor of drug-induced cell death in colon cancer cells
We investigated the role of the divergent transforming growth factor-β superfamily member, prostate-derived factor (PDF), in regulating response to chemotherapies used in the treatment of colorectalExpand
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Dysfunction of p53 in photocarcinogenesis.
The tumor suppressor protein p53 plays a critical role in the orchestration of the cellular responses to a variety of genotoxic and cytotoxic stresses. Mutations or functional inactivation of p53Expand
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A Predictive Genetic Signature for Response to Fluoropyrimidine-Based Neoadjuvant Chemoradiation in Clinical Stage II and III Rectal Cancer
Purpose: Pre-operative chemoradiation (CRT) is currently the standard of care for patients with clinical stage II and III rectal cancer but only about 45% of patients achieve tumor downstaging andExpand
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Identification of predictive markers of response to 5-Fluorouracil and oxaliplatin in metastatic colorectal cancer
Proc Amer Assoc Cancer Res, Volume 47, 2006 3390 Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the Western world. The most active drug against this malignancy isExpand