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Mycophenolic acid (MPA) is an inosine monophosphate dehydrogenase inhibitor whose antiviral mechanism of action is supposed to interfere with NAD(+)/NADH conversion. Its effects on trans-plasma membrane electron transport (t-PMET) and on trans-plasma membrane electric potential (t-PMEP), which are involved in the NAD(+)/NADH conversion, were investigated… (More)
Antiviral drugs have demonstrated significant therapeutic potential against phytoviruses, such as inosine monophosphate dehydrogenase inhibitors like mycophenolic acid or thiopurines. However, drug delivery across cellular barriers is a challenging task that calls for investigation. In this study, membrane transport of three antiviral drugs such as… (More)
KEYWORDS antiviral agents; chemotherapy; polyamidoamine; multivalency.
Electrophysiological techniques were applied to investigate the action of antiviral drugs during trans-plasma events in in vivo grapevine cells infected by GLRaV-1 and GLRaV-3. Carbon fiber microelectrodes and redox-sensitive dyes were used to measure trans-plasma membrane electron transport (t-PMET) activity in healthy and infected samples treated with… (More)
Food contamination by toxic pesticides has induced intense research for alternative methods to control pests and diseases. For instance, the phasing out of methyl bromide used for soil disinfection has led to a reconsideration of heat-based methods to control soil-borne pathogens. Techniques such as soil steaming and soil solarization have been applied… (More)
KEYWORDS virus sanitation; in vitro explants; antiviral mechanism; virus longevity.
Automation in agriculture should improve plant health, product quality, and production efficiency. However the actual use of electronic identification tools in agriculture is limited. Therefore, I review here electronic identification applications to support plant health and production and agricultural sustainability. The major points are as follows: (1)… (More)
A traceable declaration of health is now necessary for many plants, especially those being monitored for disease such as certified nursery stock. Radio-frequency identification (RFID) micro-chips placed in woody plants can be used to store and retrieve information on their health status through all phases of propagation and in the field. The microchip is… (More)
In many European rural areas, agriculture is not only an economic activity, but it is strictly linked to environmental and social characteristics of the area. Thus, sometimes, a pathogen can become a social threat, as in the case of Xylella fastidiosa and olive trees (Olea europaea L.) in Salento. Fast and systemic response to threats represents the key to… (More)