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ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATMExpand
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The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.
The integrity of genomic DNA is continuously challenged by the presence of DNA base lesions or DNA strand breaks. Here we report the identification of a new DNA damage response protein, SMARCAL1Expand
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A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.
Replication stress involving collision of replisomes with camptothecin (CPT)-stabilized DNA-Topoisomerase I adducts activates an ATR-dependent pathway to promote repair by homologous recombination.Expand
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DNA double strand breaks activate a multi-functional genetic program in developing lymphocytes
DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaksExpand
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Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
A hallmark of the cellular response to DNA double-strand breaks (DSBs) is histone H2AX phosphorylation in chromatin to generate gamma-H2AX. Here, we demonstrate that gamma-H2AX densities increaseExpand
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Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential
Cancer Gene Islands Human tumors are riddled with genomic alterations that rearrange, remove, amplify, or otherwise disrupt a wide spectrum of genes, and a key challenge is identifying which of theseExpand
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The Human Heart Contains Distinct Macrophage Subsets with Divergent Origins and Functions
Paradigm-shifting studies in the mouse have identified tissue macrophage heterogeneity as a critical determinant of immune responses. In contrast, surprisingly little is known regarding macrophageExpand
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Dynamic regulation of c‐Myc proto‐oncogene expression during lymphocyte development revealed by a GFP‐c‐Myc knock‐in mouse
c‐Myc induces widely varying cellular effects, including cell proliferation and cell death. These different cellular effects are determined, in part, by c‐Myc protein expression levels, which areExpand
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ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes
DNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia mutated (ATM) kinase, which suppresses illegitimate joining of DSBs and activates cell-cycle checkpoints. HereExpand
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β-Catenin induces T-cell transformation by promoting genomic instability
Significance Understanding molecular mechanisms that underlie genomic instability will remove a major obstacle to effective treatment of cancer. Here we characterize a unique animal model that allowsExpand
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