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  • Wolfgang Eberhardt, Andrea Huwiler, Krzysztof Beck, Sebastian Walpen, Josef M. Pfeilschifter
  • Biology, Medicine
  • The Journal of Immunology
  • 2000 (First Publication: 15 November 2000)
  • The modulation of cell signaling by free radicals is important for the pathogenesis of inflammatory diseases. Recently, we have shown that NO reduces IL-1β-induced matrix metalloproteinase (MMP-9)Continue Reading
  • Anke Doller, Andrea Huwiler, Roswitha Mueller, Heinfried H Radeke, Josef M. Pfeilschifter, Wolfgang Eberhardt
  • Medicine, Biology
  • Molecular biology of the cell
  • 2007 (First Publication: 14 March 2007)
  • In this study, we investigated the molecular mechanisms underlying the ATP analogue adenosine-5'-O-(3-thio)triphosphate-induced nucleocytoplasmic shuttling of the mRNA stabilizing factor HuR in humanContinue Reading
  • Anke Doller, el-Sayed Akool, +4 authors Wolfgang Eberhardt
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 2008 (First Publication: 19 February 2008)
  • ABSTRACT The mRNA stabilizing factor HuR is involved in the posttranscriptional regulation of many genes, including that coding for cyclooxygenase 2 (COX-2). Employing RNA interference technology andContinue Reading
  • Cuiyan Xin, Shuyu Ren, +6 authors Andrea Huwiler
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2004 (First Publication: 20 August 2004)
  • Exposure of renal mesangial cells to sphingosine 1-phosphate (S1P) leads to a rapid and transient activation of the mitogen- and stress-activated protein kinases but also the protein kinase B. Here,Continue Reading
  • Frauke Döll, Josef M. Pfeilschifter, Andrea Huwiler
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2005 (First Publication: 30 December 2005)
  • Sphingosine 1-phosphate (S1P) the product of sphingosine kinase (SK) action plays an important role in various pathological conditions like inflammation and cancer. In this study, we show that in theContinue Reading
  • Frauke Döll, Josef M. Pfeilschifter, Andrea Huwiler
  • Medicine, Biology
  • Endocrine-related cancer
  • 2007 (First Publication: 1 June 2007)
  • Sphingosine kinases (SK) catalyze the formation of sphingosine-1-phosphate (S1P) which plays a crucial role in cell growth and survival. Here, we show that prolactin (PRL) biphasically activates theContinue Reading
  • Andrea Huwiler, Josef Brunner, +4 authors Josef M. Pfeilschifter
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 9 July 1996)
  • Interleukin 1 is the prototype of an inflammatory cytokine, and evidence suggests that it uses the sphingomyelin pathway and ceramide production to trigger mitogen-activated protein kinase (MAPK)Continue Reading