Andrea Harkin

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The two purposes of this study were to develop a clinical test of surgical resident proficiency and to compare this clinical test with currently applied methods of resident evaluation. Appendicitis is a common surgical disease, and its accurate diagnosis depends largely on clinical acumen. Ten third-year surgical residents prospectively evaluated 107(More)
Background In a non-inferiority study where the aim is to compare a reduced treatment duration there is a choice of two randomisation time-points. Patients can be randomised at the end of the reduced treatment period to continue or not to the standard duration. This is optimum for maximising compliance, but has the disadvantage for the patient that(More)
Background The SCOT colorectal cancer trial is a phase III randomised controlled, multi-centre, non-inferiority trial comparing the efficacy of 12 weeks of chemotherapy versus 24 weeks and the associated toxicity, along with a lifetime economic analysis. The economic analysis will use prospective trial data to inform a lifetime cost-effectiveness model.(More)
e14145 Background: Colorectal cancer is one of the leading causes of cancer mortality worldwide. Many large randomized clinical trials have established a benefit for adjuvant 5-fluorouracil (5-FU) based chemotherapy in this disease. More recently the NSABP C-07 and MOSAIC trials have shown a benefit for the addition of oxaliplatin to adjuvant treatment, but(More)
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