Andrea Gonnermann

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Meta-analysis plays an important role in the analysis and interpretation of clinical trials in medicine and of trials in the social sciences but is of importance in other fields (e.g., particle physics [1]) as well. In 2001, Hartung and Knapp [2,3] introduced a new approach to test for a nonzero treatment effect in a meta-analysis of k studies. Hartung and(More)
UNLABELLED Although sofosbuvir has been approved for patients with genotypes 2/3 (G2/3), many parts of the world still consider pegylated Interferon alpha (P) and ribavirin (R) as standard of care for G2/3. Patients with rapid virological response (RVR) show response rates >80%. However, SVR (sustained virological response) in non-RVR patients is not(More)
In the context of both drug licensing and reimbursement, the target population is sometimes restricted to a specific subgroup. In the setting of drug licensing the discussion concerns a negative benefit/risk assessment in a relevant subgroup. For reimbursement the debate involves the detection of an additional benefit compared with standard treatment, which(More)
Evidence based recommendations can significantly aid decision processes in medicine and mobile apps are starting to enter this domain. Considering the rapid access to and quick processing of information made possible by such apps, it is especially important to ensure the quality and structure of the provided data and to also keep the limitations of the(More)
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