Andrea Freshler

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The distribution of radioiodinated N-methyl-4-(4-hydroxy-3-iodobenzyl)-1,2,3,6-tetrahydropyridine (MHTP), an analog of the reportedly nontoxic N-methyl-4-benzyl-1,2,3,6-tetrahydropyridine, (4-homo-MPTP), has been studied in the primate. [123I]MHTP-derived radioactivity exhibited a progressive accumulation and prolonged retention within the primate eye.(More)
Arylsulfatases (EC 3.1,6.1) are hydrolytic enzymes that catalyze the removal of sulfate groups from a variety of aromatic and complex aliphatic molecules. Although these enzymes have been purified and characterized in mammals and many of the in vivo substrates have been identified, virtually nothing is known about their function in insects. Yang et al.(More)
Eighteen analogues of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and evaluated as substrates of monoamine oxidase. In general, the flexible analogues, characterized by the presence of a methylene (or ethylene) bridge between the aryl/heteroaryl and tetrahydropyridyl moieties, were better substrates of the enzyme than the(More)
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