Andrea Fiebitz

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Most of the biological processes rely on the formation of protein complexes. Investigation of protein-protein interactions (PPI) is therefore essential for understanding of cellular functions. It is advantageous to perform mammalian PPI analysis in mammalian cells because the expressed proteins can then be subjected to essential post-translational(More)
BACKGROUND Uterine leiomyomas are the most common benign tumours in women, which arise from smooth muscle cells of the uterine myometrium and usually are multicentric. In spite of their frequency pathogenesis is widely unknown, mainly due to the absence of a suitable model system. We describe the systematic optimization of culturing leiomyoma tissue(More)
Nervenfasern konnten im eutopen Endometrium von Patientinnen mit Endometriose sowie in ektopen Endometrioseläsionen nachgewiesen werden. Zwei pathophysiologische Hypothesen werden hinsichtlich des Vorkommens von Nervenfasern sowohl im Endometrium als auch in ektopen Läsionen kontrovers diskutiert: Ist das Vorkommen von Nervenfasern ein rein(More)
Trisomy of human chromosome 21 (Chr21) results in Down's syndrome, a complex developmental and neurodegenerative disease. Molecular analysis of Down's syndrome, however, poses a particular challenge, because the aneuploid region of Chr21 contains many genes of unknown function. Subcellular localization of human Chr21 proteins may contribute to further(More)
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