BACKGROUND HLA-DM (DM) mediates exchange of peptides bound to MHC class II (MHCII) during the epitope selection process. Although DM has been shown to have two activities, peptide release and MHC class II refolding, a clear characterization of the mechanism by which DM facilitates peptide exchange has remained elusive. METHODOLOGY/PRINCIPAL FINDINGS We… (More)
In this paper we present a novel methodology based on a topological entropy, the so-called persistent entropy, for addressing the comparison between discrete piecewise linear functions. The comparison is certified by the stability theorem for persistent entropy. The theorem is used in the implementation of a new algorithm. The algorithm transforms a… (More)
The mechanism of HLA-DM (DM) activity is still unclear. We have shown that DM-mediated peptide release from HLA-DR (DR) is dependent on the presence of exchange peptide. However, DM also promotes a small amount of peptide release in the absence of exchange peptide. Here we show that SDS-PAGE separates purified peptide/DR1 complexes (pDR1) into two… (More)
In this paper we present a novel methodology based on a topological entropy, the so-called persistent entropy, for addressing the comparison between discrete piece-wise linear functions. The comparison is certified by the stability theorem for persistent entropy. The theorem is used in the implementation of a new algorithm. The algorithm transforms a… (More)
—Recent evolution in regulation of access to TV channels allocated in UHF frequencies (DVB-T) makes vacant channels (TV White Spaces-TVWS) available to wireless data services. While this opportunity is currently widely studied by the cognitive radio community for communications, the use of TVWS for indoor positioning is all but unexplored. Frequencies below… (More)
The adaptive immune response begins when CD4+ T cells recognize antigenic peptides bound to class II molecules of the Major Histocompatibility Complex (MHCII). The interaction between peptides and MHCII has been historically interpreted as a rigid docking event. However, this model has been challenged by the evidence that conformational flexibility plays an… (More)
Approvazione verbale riunione precedente Il Direttore porta all'approvazione del Collegio il verbale della seduta del Collegio del 25/01/2011. Il Collegio approva all'unanimità.