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  • Jeffrey S. Martini, Philip W J Raake, +7 authors Walter J. Koch
  • Biology, Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • 2008 (First Publication: 26 August 2008)
  • G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs important for myocardial regulation, andExpand
  • Andrea D. Eckhart, Tohru Ozaki, Hendrik Tevaearai, Howard A. Rockman, Walter J. Koch
  • Biology, Medicine
  • Molecular pharmacology
  • 2002 (First Publication: 1 April 2002)
  • Cardiovascular regulation is tightly controlled by signaling through G protein-coupled receptors (GPCRs). beta-Adrenergic receptors (ARs) are GPCRs that regulate inotropy and chronotropy in the heartExpand
  • Heather Irina Cohn, David M. Harris, +5 authors Andrea D. Eckhart
  • Medicine, Biology
  • American journal of physiology. Heart and…
  • 2008 (First Publication: 22 August 2008)
  • G protein-coupled receptor kinase 2 (GRK2) is a serine/theorinine kinase that phosphorylates and desensitizes agonist-bound G protein-coupled receptors. GRK2 is increased in expression and activityExpand
  • Jihee Kim, Andrea D. Eckhart, Satoru Eguchi, Walter J. Koch
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 30 August 2002)
  • Cardiac hypertrophy often leads to heart failure and is associated with abnormal myocardial adrenergic signaling. This enlargement of myocardial mass can involve not only an increase in cardiomyocyteExpand
  • Henriette Brinks, Matthieu Boucher, +11 authors Walter J. Koch
  • Medicine
  • Circulation research
  • 2010 (First Publication: 29 October 2010)
  • Rationale: Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein–coupled receptors (GPCRs) protects myocardium in ischemia/reperfusion injury (I/R)Expand