Andrea D’Ávila Freitas

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Drug interactions involving protease inhibitors are common. Protease inhibitors are well known inhibitors of the 3A4 isozyme of cytochrome P450. Select protease inhibitors, including co-formulated lopinavir/ritonavir, may induce glucuronidation or the activity of other CYP450 isozymes. We describe the case of a patient taking warfarin who experienced a(More)
An 18-year-old male student presented to the hospital complaining of abdominal pain, fever, and 4 kg weight loss in the preceding 2 months. Six weeks before the beginning of the symptoms , the patient reported a cliff fall when he was practicing longboard at Alto da Boa Vista, an urban forest area in Rio de Janeiro, Brazil. For almost 30 minutes he remained(More)
Paracoccidioidomycosis (PCM) is a neglected systemic mycosis endemic to Latin America caused by dimorphic fungi of the genus Paracoccidioides. The acute juvenile PCM is a severe type of presentation that usually affects young vulnerable patients and rarely progresses to portal hypertension. Here, two cases of liver disease and portal hypertension as(More)
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