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The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1 plays a dual role in two apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling. Here, we show that brain-derived neurotrophic factor (BDNF)-driven(More)
The Fragile X syndrome (FXS) is the most frequent form of inherited mental retardation and also considered a monogenic cause of Autism Spectrum Disorder. FXS symptoms include neurodevelopmental delay, anxiety, hyperactivity, and autistic-like behavior. The disease is due to mutations or loss of the Fragile X Mental Retardation Protein (FMRP), an RNA-binding(More)
Cognitive and motor performances decline during aging. Although it is clear that such signs reflect synaptic compromise, the underlying mechanisms have not been defined. We found that the levels and activity of the synaptic plasticity modulators phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P₂) and phospholipase Cγ (PLCγ) were substantially reduced in(More)
Sommario: Viene presentato uno strumento grafico per lo sviluppo in-the-large di applicazioni con esigenze di dependability ("adeguata affidabilità"); le applicazioni vengono sviluppate in forma grafica e rese anche in forma testuale, a beneficio di ulteriori fasi di sviluppo o verifica. In particolare, vengono evidenziate le facilitazioni per inserire(More)
The improvement of Quantitative Precipitation Forecast (QPF) in mountainous area was the central supporting objective of the MAP project P1 devoted to the study of orographic precipitation. This paper attempts to review the main MAP-related achievements towards QPF improvement and to highlight the MAP-impact for developing QPF research and operational(More)
Molecular organization of the pre-and postsynaptic scaffold: 1. Uli Thomas, Stephan Sigrist: Glutamate receptors in synaptic assembly and plasticity â€â€oe case studies on fly NMJs. intellectual disability. Aspects of Mental Retardation in The Fragile X Syndrome: from gene mutation/s to spine dysmorphogenesis. Luca: Synaptic dysfunction in(More)
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