Andrea Besecke

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Mice homozygous for the Extra-toes mutation (Xt/Xt) die perinatally with multiple malformations involving the brain, the eye, the nasal mucosa, the face and the skeleton. We have investigated the development of the eye defect in Xt/Xt embryos until late gestation. In early midgestation, three classes of homozygotes can be identified: some form an apparently(More)
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