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  • G Robbin Westerhof, Jan H. Schornagel, +7 authors Herbert Michael Pinedo
  • Biology, Medicine
  • Molecular pharmacology
  • 1995
  • The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro against human and murine cell lines expressing different levels of theExpand
  • Joel E. Wright, Chitra M. Vaidya, Ying-nan Chen, Andre Rosowsky
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2000 (First Publication: 1 July 2000)
  • The potent nonpolyglutamatable dihydrofolate reductase inhibitor N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-o rnithine (PT523) and six of its B-ring (5-deaza, 8-deaza, andExpand
  • Andre Rosowsky, Hubert Dr. Bader, Costanza Anellamaria Cucchi, Richard G. Morán, William Kohler, James H. Freisheim
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1988 (First Publication: 1 July 1988)
  • N delta-Acyl derivatives of the potent folylpolyglutamate synthetase (FPGS) inhibitor N alpha-(4-amino-4-deoxypteroyl)-L-ornithine (APA-L-Orn) were synthesized from NExpand
  • Andre Rosowsky, Hongning Fu, David C. M. Chan, Sherry F. Queener
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2004 (First Publication: 1 May 2004)
  • Six previously undescribed N-(2,4-diaminopteridin-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy side chains at the 2'-position were synthesized andExpand