Andre R.O. Cavalcanti

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What is spliced leader (SL) trans-splicing? It is an mRNA maturation process, similar to intron splicing, which has been shown to occur in a limited number of eukaryotes. In SL trans-splicing, the cell replaces nucleotides at the 5′ end of some pre-mRNAs with those of a special class of small nuclear RNAs, called SL RNAs. These are short molecules with two(More)
To evaluate the prevalence of genetic defects in clinically suspected autoinflammatory syndromes (AIS) in a Brazilian multicenter study. The study included 102 patients with a clinical diagnosis of Cryopyrin Associated Periodic Syndromes (CAPS), TNF Receptor Associated Periodic Syndrome (TRAPS), Familial Mediterranean Fever (FMF), Mevalonate Kinase(More)
New studies are challenging the invariance of the building blocks of naturally occurring proteins by incorporating unnatural amino acids in the genetic code. These methodologies hold great promise for the study of genetic code evolvability. The genetic code encodes 20 amino acids in almost all living cells; the only known exceptions are a few organisms that(More)
What is it? As we all learned in high school, the so-called 'universal' or standard genetic code is the set of rules that define the correspondence between the '20' amino acids in proteins and groups of 'three' bases (codons) in the mRNA. Is the code universal? No. Although most organisms have the same genetic code, researchers began to discover exceptions(More)
Gene fusions, yielding the formation of multidomain proteins, are evolutionary events that can be utilized as phylogenetic markers. Here we describe a fusion gene comprising the α and β subunits of succinyl-coA synthetase, an enzyme of the TCA cycle, in Pezizomycotina fungi. This fusion is present in all Pezizomycotina with complete genome sequences and(More)
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