Andre Macedo

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Agricultural resource derivatives (ARDs) such as hydrolysate soy protein concentrate (HSPC), whey protein concentrate (WPC), and cashew apple juice (CAJ) were studied with focus on the production of hyaluronic acid (HA) by Streptococcus zooepidemicus. Supplementation of the media with corn steep liquor (CSL) was also evaluated. Synthetic medium containing(More)
Large-scale RNAi-based screens are a major technology, but require adequate prioritization and validation of candidate genes from the primary screen. In this work, we performed a large-scale pooled shRNA screen in mouse embryonic stem cells (ESCs) to discover genes associated with oxidative stress resistance and found several candidates. We then developed a(More)
The distribution of micro-organisms in mature Serra, a traditional Portuguese cheese made from unpasteurised ewes' milk without added starter culture, was examined by light microscopy and electron microscopy. Four populations of micro-organisms were recognized according to their position within the cheese: (i) those present as apparently axenic colonies(More)
Diabetic Retinopathy (DR) is one of the major complications of diabetes mellitus and can cause blindness. The diagnosis of DR is performed by visual analysis of retinal images being exudates (fat deposits) the mains patterns traced by a specialist doctor. This paper presents a new method for DR detection in color retinal images. The proposed algorithm(More)
The rates and extents of hydrolysis of alpha(S)- and beta-caseins from bovine, caprine, and ovine sodium caseinates produced by an enzymatic extract of the fruit of Opuntia ficus-indica, (L.) Miller were evaluated and compared with those produced by a commercial animal rennet. A mechanistic model based on a pseudo-first-order enzymatic reaction, in the(More)
Hyaluronic acid is a polysaccharide of the glycosaminoglycan family present in mammal tissues. In the eye, it can be found in the cornea, the sclera and the vitreous humor. Currently, it has been employed in several medical specialties, including ophthalmology. The objective of this paper is to demonstrate the various current and future ophthalmic(More)
This paper proposes an architecture to classify traffic flows of IP access networks, and signalize to hybrid optical network the most appropriate paradigm, Optical Circuit Switching (OCS) and Optical Burst Switching (OBS), to be used. The concept of software defined networks, more specifically the OpenFlow technology, was used to enable the architecture.(More)
Diabetic Retinopathy (DR) is one of the major complications of diabetes mellitus and can cause blindness. The diagnosis of DR is performed by visual analysis of retinal images, with exudates (fat deposits) being the main patterns traced by a specialist doctor. Thus, this paper proposes an algorithm for exudate detection in retinal images, whose experimental(More)
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