Andreĭ Petrovich Milovanov

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The aim was to determine whether the fetal vasculature of the human placenta adapts in a uniform manner to different forms of hypoxic stress. Stereological analyses were performed on the intermediate and terminal villi of placentae obtained from each of the following conditions; high altitude (up to 2800 m), maternal iron-deficiency anaemia and(More)
In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal cells and extracellular matrix proteins(More)
Confocal and conventional indirect immunofluorescence and immunogold electron microscopic methods were applied to examine the distribution of extracellular matrix constituents (collagens types III and IV) in the villi of immature and term human placentae. The immunofluorescence study revealed that collagen type III is more distinct in the villous stroma of(More)
OBJECTIVE Our purpose was to determine whether the human placenta is able to adapt structurally to hypobaric hypoxia so as to increase its diffusing capacity. STUDY DESIGN Material from 10 normal term placentas collected at each of three altitudinal levels in Kirghizstan was analyzed stereologically. Data were compared by one-way analysis of variance. (More)
The comparison of the spiral uterine arteries structure, umbilical vessels and placenta is performed in 16 women with normal haemodynamics and in 31 women with disturbances of mother-foetus circulation, and the data obtained were compared with results of dopplerometry made before the delivery. Three clinical groups are distinguished according to the(More)
Distribution of collagen types I, III, IV, V and fibronectin in human placental villi has been studied by indirect immunofluorescence. During 9-12 weeks of pregnancy the extracellular matrix of villi represents a network of filaments organized in bundles and aggregates that contain collagen types I and III and finer filaments of collagen types IV and V.(More)
OBJECTIVES Our purpose was to determine the effects of pregnancy at high altitude on the human placental structure. STUDY DESIGN Histologic material from 22 term placentas delivered at altitudes above 3600 m was examined and compared with control material from 760 m. RESULTS Intraplacental chorioangiomas were identified in 5 of the 22 high-altitude(More)
Six basic mechanisms facilitating development of chronic placental deficiency, hypotrophy and fetal death are distinguished: 1) insufficiency of invasion of the extra-villous cytotrophoblast into the placental bed resulting in incomplete gestational restructuring of spiral arteries and reduction of uteroplacental circulation; 2) rheological disturbances in(More)
VEGF expression was immunohistochemically studied in 35 placental fragments and 15 placental bed biopsy specimens in a control group and in 34 placental fragments and 16 biopsy specimens in women with preeclampsia. The female serum concentrations of VEGF and sFlt-I were measured in both groups. There was a drastic reduction in VEGF expression in the(More)
OBJECTIVE To estimate the intensity of immunoexpression of matrix metalloproteinases type 2 and type 9 (MMP-2 and MMP-9) during cytotrophoblast invasion (CTI) in the uteroplacental region. MATERIALS AND METHODS There were 6 groups: 1) medical abortions at 7 to 8 weeks' gestation; 2) amputated uteri at 9 to 12 weeks; 3) late medical abortions at 18 to 24(More)