Andrés Valdivieso

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BACKGROUND Pathogen-associated molecular patterns (PAMP) receptors play a key role in the early host response to viruses. In this work, we determined mRNA levels of two members of the Toll-like Receptors family, (TLR3 and TLR7) and the helicase RIG-I, all of three recognizing viral RNA products, in peripheral blood of healthy donors and hepatitis C virus(More)
To define and validate a pharmacokinetic (PK) model for tacrolimus (TAC) that includes patient pathophysiology and has clinical applicability in the first 2 weeks post-liver transplantation (PLT). Routine monitoring records [dose, trough levels (Cmin), demographics, biochemistry] from 75 patients treated with TAC (Prograf®) PLT were used to develop a(More)
BACKGROUND Both dietary phosphorus restriction and the ingestion of ammonium chloride (NH(4)Cl) given to rats on a high-phosphorus diet have been shown to preserve renal function in the azotaemic rat. Parathyroidectomy also has been reported to preserve renal function and, in addition, to prevent kidney hypertrophy in the remnant kidney model. Our goals(More)
BACKGROUND Kidney hypertrophy is stimulated by both partial nephrectomy and NH(4)Cl administration. Also, parathyroidectomy (PTX) has been reported to prevent kidney hypertrophy induced by a high protein diet. Our goal was to determine in the azotaemic rat: (i) the combined effects of NH(4)Cl administration and dietary phosphorus on the development of(More)
The authors acknowledge the constructive comments and assistance from anonymous referees in the preparation of this paper. Abstract Australia has reduced its international trade barriers by signing Free Trade Agreements (FTAs). These FTAs have brought benefits to some sectors of the economy, along with threats to some firms in local industries. The recent(More)
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