Andrés López García

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Liver extract, plasma from intact mice, ES2 tumour extract and plasma from tumour bearing mice has an inhibiting effect on the mitotic activity of hepatocytes and duodenal enterocytes. In the present experiments, the effect of these treatments on the mitotic activity of renal tubular cells was studied. C3HS 28 day-old male mice, standardized for periodicity(More)
This work was designed to characterize in anesthetized goats the hemodynamic response of the carotid rete during pharmacologically induced changes in systemic blood pressure or blood flow to the brain. Under control conditions, mean blood pressure in the middle cerebral artery (distal to rete) was 18% lower than that measured in the internal maxillary(More)
Angiogenesis is an essential process in the progression of malignant tumors and the most potent angiogenic factor is the vascular endothelial growth factor (VEGF). On the other hand, the CD34 is an endothelial antigen that has been used to highlight the microvasculature vessel density (MVD) as a direct marker of the degree of neoangiogenesis. In the present(More)
In liver regeneration the formation of new capillary blood vessels is a fundamental requirement for cellular proliferation. Vascular endothelial growth factor (VEGF) is involved in the events of angiogenesis, the mRNA of which is expressed in both hepatocytes and non-parenchymal cells. In this experimental design we try to establish if during liver(More)
The carotid rete of Artiodactyla, an intracranial arterial plexus which supplies blood to the brain, has intrigued investigators for a long time. This study was designed to examine the responsiveness of isolated retial arteries (250-700 microns in external diameter) of goat, pig, and cattle. The findings in these arteries were compared to those observed in(More)
Myasthenia gravis (MG) is an autoimmune disease with an incidence of 2-10/100,000 cases per year, characterized by muscle weakness secondary to destruction of postsynaptic acetylcholine receptors. In these patients, important perioperative issues remain unresolved, namely, optimal administration of cholinesterase inhibitors, risks of regional anesthesia,(More)
OBJECTIVE To determine the incidence of paresthesia with different spinal puncture techniques using a 27-gauge Whitacre needle. MATERIAL AND METHODS Spinal puncture was performed in 224 elective cesarean sections using different techniques in this single-blind, prospective trial. Patients were randomized to 4 groups: group 1, combined epidural and(More)
We have previously demonstrated that liver extract, when administered at 16:00 hr, inhibits the mitotic activity of hepatocytes and renocytes at 08:00, 12:00 and 16:00 hr. during the following 2 days. The experiments reported here were designed to achieve an initial characterization of this liver mitostatic activity. For these studies we used 28-days-old(More)
Inbred C3HS male mice, standardized for periodicity analysis were used. A hundred and seventy 25 +/- 2 days old mice were injected at 16:00 hs with saline, plasma or liver extract from 27 mice 90 days old. Controls were made at 08/16, 12/20, 16/24, 08/40, 12/44, 16/48, 08/64, 12/68 and 16/72 (time of day/time post-injection). The mitotic activity of the(More)
In the present experiments we studied the effect of extracts from intact liver (LE), ES2 tumor extract (TE), plasmas from intact mice (PI), and from tumor bearing animals (PT) on different phases of hepatocytes and renocytes cell cycles. C3HS 28-day-old male mice, standardized for periodicity analysis, were injected at 16:00 hours and killed every 4 hours(More)