Andrés F. Flórez

Learn More
Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the emergence of resistant strains. The outlook is worsened by the absence of promising drug targets for this disease. We have taken a computational approach to the detection of new drug targets,(More)
OBJECTIVE To identify and characterize high-order gene-to-gene interactions in antisocial personality disorder (ASPD). METHODS Participants for case-control study were selected from the inmate male population in Bellavista prison from Medellin. The study included 310 individuals with ASPD and 200 with no ASPD. Diagnoses were made according to a(More)
The trypanosomatid protozoa Leishmania is endemic in ~100 countries, with infections causing ~2 million new cases of leishmaniasis annually. Disease symptoms can include severe skin and mucosal ulcers, fever, anemia, splenomegaly, and death. Unfortunately, therapeutics approved to treat leishmaniasis are associated with potentially severe side effects,(More)
While many tumors initially respond to chemotherapy, regrowth of surviving cells compromises treatment efficacy in the long term. The cell-biological basis of this regrowth is not understood. Here, we characterize the response of individual, patient-derived neuroblastoma cells driven by the prominent oncogene MYC to the first-line chemotherapy, doxorubicin.(More)
Andrés F. Flórez1,2, Stanley Watowich3 and Carlos Muskus2 1German Cancer Research Center (DKFZ)/ Division Theoretical Systems Biology, Heidelberg 2Universidad de Antioquia/Programa de Estudio y Control de Enfermedades Tropicales – PECET, Medellín 3University of Texas Medical Branch/Department of Biochemistry and Molecular Biology and the Sealy Center for(More)
  • 1