André Thomas

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Impulsivity, often defined as a human behavior characterized by the inclination of an individual to act on urge rather than thought, with diminished regard to consequences, encompasses a range of maladaptive behaviors, which are in turn affected by distinct neural systems. Congruent with the above definition, behavioral studies have consistently shown that(More)
BACKGROUND Substance-abusing individuals tend to display abnormal reward processing and a vulnerability to being impulsive. Detoxified alcoholics show differences in regional brain activation during a monetary incentive delay task. However, there is limited information on whether this uncharacteristic behavior represents a biological predisposition toward(More)
BACKGROUND Abnormal function in reward circuitry in cocaine addiction could predate drug use as a risk factor, follow drug use as a consequence of substance-induced alterations, or both. METHODS We used a functional magnetic resonance imaging monetary incentive delay task (MIDT) to investigate reward-loss neural response differences among 42 current(More)
Nowadays, managing correctly the always changing customer demands is a challenge for companies, especially because of its impact on the Supply Chain (Forrester effect). Tactical planning is very useful in establishing robust plans. This paper proposes an alternative policy to traditional practices (frozen horizon ...), the so-called “reference plan”, to(More)
The economic context leads companies to answer quickly to the unpredictable changing customer demands. Advanced Planning Systems (APS) are useful tools to set up quickly Sales and Operations Planning (SOP) and Master Production Schedules (MPS). The problem is to obtain stable plans and schedules in spite of the unstable demand. In this paper, we propose a(More)
In new Intelligent Manufacturing Systems, Product Driven Systems (PDS) architectures require emulation tool (Thomas et al. 2008) to be developed. Discrete events simulation is often used to build such emulation tool, nevertheless this remains complex because of large scale problems. The goal of this paper is to propose a way to design a simulation model by(More)
Product-driven control may enable manufacturing companies to meet business demands more quickly and effectively. But a key point in making this concept acceptable by industry is to provide benchmarking environments in order to compare and analyze their efficiency on emulated large-scale industry-led case studies with regard to current technologies and(More)
Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in(More)
Résumé— La simulation est souvent utilisée pour évaluer la pertinence d’un Programme Directeur de Production (PDP) ou pour en évaluer l’impact sur des scénarii d’ordonnancement détaillés de la fabrication. Dans ce cadre, nous nous proposons de réduire la complexité d’un modèle de simulation en exploitant un perceptron multicouches. Une phase primordiale(More)