PURPOSE In children with intermediate risk of relapse of acute lymphoblastic leukemia (ALL), it is essential to identify patients in need of treatment intensification. We hypothesized that the prognosis of patients with unsatisfactory reduction of minimal residual disease (MRD) can be improved by allogeneic hematopoietic stem-cell transplantation (HSCT). … (More)
Background: Circulating levels of tumor necrosis factor (TNF) and lymphotoxin-α (LT-α) have been associated with outcome in solid and hematologic malignancies. Within the TNF gene and the LT-α gene, polymorphisms have been identified at nucleotide positions-308 and +252, respectively. The variant alleles for TNF are designated TNF1 and TNF2, the ones for… (More)
We report on an 8 year old boy with primary cardiac anaplastic large cell lymphoma (ALCL), in whom the diagnosis was challenging and who was treated with modified chemotherapy without radiation therapy according to the ALCL 99 study protocol . Two years and 4 months after completion of therapy the boy is in complete remission with normal cardiac function.
response in childhood acute lymphoblastic leukemia Distinct gene expression profiles determine molecular treatment Information about subscriptions and ASH membership may be found online at: .
response in childhood acute lymphoblastic leukemia Distinct gene expression profiles determine molecular treatment Updated information and services can be found at: (4217 articles) Neoplasia (149 articles) Genomics (1086 articles) Gene Expression (3667 articles) Clinical Trials and Observations Articles on similar topics can be found in the following Blood… (More)