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BACKGROUND/AIMS It was the aim of this study to carry out a comparative evaluation in vitro on standardized color charts and in vivo on healthy subjects using the Visi-Chroma VC-100, a new imaging tristimulus colorimeter and the Minolta Chromameter CR-200 as a reference instrument. The Visi-Chroma combines tristimulus color analysis with full color(More)
The measurement of transepidermal water loss (TEWL) is an important noninvasive method in order to assess the barrier function of the stratum corneum. As a consequence, TEWL has been found to be a very useful technique for studying skin irritation induced by various physical and chemical effects. Exposure of the skin to chemicals (detergents) and physical(More)
The purpose of the study was to evaluate the trauma induced by insertion of the linear microdialysis probe in the subcutaneous and dermal tissue in the rat and to check if the microdialysis probe insertion affects transdermal drug delivery. Non-invasive bioengineering methods (TEWL, Laser Doppler Velocimeter, Chromameter) as well as histology were combined(More)
Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to increase the(More)
The preservative properties of thyme essential oil (3%) with a known composition were evaluated in two types of final formulations, suitable for use as pharmaceutical or cosmetic vehicles, by means of a standard challenge test proposed by the latest European Pharmacopoeia. The required preservation efficacy criteria were satisfied against the bacterial(More)
The appearance of hair plays an important role in people's overall physical appearance and self-perception. Silicon (Si) has been suggested to have a role in the formation of connective tissue and is present at 1-10 ppm in hair. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to improve skin microrelief and(More)
AIM There is scarce information concerning the pharmacodynamic behavior of topical substances used in the physiotherapy setting. The aim of the present study was to estimate the formation and emptying of the diclofenac (DF) skin reservoir after passive, semiocclusive, and electrically assisted applications of DF. SUBJECTS AND METHODS Five different groups(More)
BACKGROUND/AIMS The visual appearance of cellulite or the'orange peel'look of skin is a common cosmetic problem for many women. Cellulite, or more correctly lipodystrophy, is a modification of the adipose tissue, whereby the fat lobules are swollen as the result of a disturbed blood and lymph micro-circulation and fibrosclerose of connective tissue. In the(More)
BACKGROUND/AIMS A major problem with electrical measurements of the capacitance of the skin using the well kwown capacitance method (Corneometer) resides in the fact that the results of this instrument are expressed as arbitrary capacitance hydration units that are not directly related to real electrical units or to the water content of the horny layer. The(More)
BACKGROUND Measurement of stratum corneum (SC) hydration often involves the use of commercial instruments. The aim of this study was to compare and validate two recent instruments: the Corneometer 825® (digital probe) and the Skicon-200 EX®. METHODS In vitro calibration was carried out on filter pads using different solvents, measurements over different(More)