André Maier

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Self-assessment of symptom progression in chronic diseases is of increasing importance in clinical research, patient management and specialized outpatient care. Against this background, we developed a secure internet platform ( that allows online assessment of the revised ALS Functional Rating Scale (ALSFRS-R) and other established(More)
UNLABELLED Preclinical studies show that blocking Interleukin-1 (IL-1) retards the progression of Amyotrophic Lateral Sclerosis (ALS). We assessed the safety of Anakinra (ANA), an IL-1 receptor antagonist, in ALS patients. In a single arm pilot study we treated 17 ALS patients with ANA (100 mg) daily for one year. We selected patients with dominant or(More)
BACKGROUND Undesirable loss of weight is a major challenge in amyotrophic lateral sclerosis (ALS). However, little is known about loss of appetite in ALS patients. OBJECTIVE We investigated loss of appetite in ALS patients by means of an online self-assessment and whether ALS-related symptoms were associated with it. METHODS Loss of appetite in 51 ALS(More)
INTRODUCTION Complex forms of spastic paraplegia (SPG) are rare and genetically heterogeneous. In apparently sporadic cases, analysis of known SPG genes often fails to reveal a mutation. METHODS We report a 24-year-old patient with a syndrome of spastic paraplegia, ataxia, frontotemporal dementia, and lower motor neuron involvement. RESULTS Screening of(More)
PURPOSE Methodological optimization of a 1H MR spectroscopic imaging sequence (1H-2D-CSI) and evaluation of its potential to diagnose prostate cancer as validated by histopathological maps. METHODS The prostates of 18 patients were evaluated by 1H-MR-CSI (voxel dimension: 1 cm3) at 1.5 Tesla. This sequence was additionally combined with a frequency(More)
Non-invasive ventilation (NIV) or tracheotomy with invasive ventilation (TIV) are treatment options in ALS. However, a proportion of patients receiving long-term ventilation decide to have it withdrawn. The objective of this study was to analyse the clinical characteristics and palliative approaches in ALS patients withdrawing from long-term ventilation(More)
Levodopa/carbidopa intestinal gel (LCIG) is a treatment for Parkinson’s disease patients with motor fluctuations refractory to conventional drug therapy. LCIG is pumped via a jejunal tube through a percutaneous endoscopic gastrostomy (Jet-PEG). Severe adverse events (SAEs) cluster shortly after Jet-PEG insertion. However, during chronic treatment (later(More)
INTRODUCTION Although diplopia is considered a frequent symptom of Parkinson's disease (PD), little is known about its clinical manifestation, associated mechanisms and treatment. Here we characterized binocular diplopia in non-demented PD patients in an interdisciplinary setting. METHODS PD patients were prospectively screened for diplopia, visual(More)
OBJECTIVES Verticality perception is known to be abnormal in Parkinson's disease (PD), but in which stage respective dysfunctions arise and how they relate to postural disorders remains to be settled. These issues were studied with respect to different dimensions of the subjective visual vertical (SVV) in relation to clinical parameters of postural control.(More)
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