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INTRODUCTION We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI). METHODS We… (More)
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk… (More)
Recently, Cruchaga et al. described the association of rare variants in the phospholipase D3 gene (PLD3) with the risk of developing Alzheimer’s disease; this observation resulted from a strategy… (More)
To follow-up loci discovered by the International Genomics of Alzheimer’s Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample… (More)
Few data are available concerning the role of risk markers for Alzheimer’s disease (AD) in progression to AD dementia among subjects with mild cognitive impairment (MCI). We therefore investigated… (More)
Alfredo Ramirez1,2,,∗, Wiesje M. van der Flier6,7,, Christine Herold8,, David Ramonet3,, Stefanie Heilmann2,4, Piotr Lewczuk9, Julius Popp1, André Lacour8, Dmitriy Drichel8, Eva Louwersheimer6,7,… (More)