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Levels of heroin and its metabolites in blood and brain extracellular fluid after i.v. heroin administration to freely moving rats.

• André Gottås, Elisabeth Leere Øiestad, +4 authors Jørg G Mørland
• British journal of pharmacology
• 2013

BACKGROUND AND PURPOSE Heroin, with low affinity for μ-opioid receptors, has been considered to act as a prodrug. In order to study the pharmacokinetics of heroin and its active metabolites after… (More)

Simultaneous measurement of heroin and its metabolites in brain extracellular fluid by microdialysis and ultra performance liquid chromatography tandem mass spectrometry.

• André Gottås, Elisabeth Leere Oiestad, +5 authors Jorg Morland
• Journal of pharmacological and toxicological…
• 2012

INTRODUCTION The pharmacokinetic profile and systemic bioavailability of a substance is often described by blood or total tissue concentrations. For centrally acting drugs, like opioids, the free… (More)

Urinary Kinetics of Heroin Metabolites in Pigs Shortly After Intake.

• Gudrun Høiseth, André Gottås, Thomas Berg, Marianne Arnestad, Per Steinar Halvorsen, Liliana C. Bachs
• Journal of analytical toxicology
• 2017

In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive… (More)

Different effects on dopamine release in nucleus accumbens in mice by the morphine metabolites morphine-6-glucuronide and morphine-3-glucuronide.

• Vigdis Vindenes, Bjørg Sjøgren Pettersen, André Gottås, Nina Lieng Christiansen, Fernando Boix, Jørg G Mørland
• Basic & clinical pharmacology & toxicology
• 2009

The mesolimbic dopamine system plays an important role in the rewarding properties of drugs of abuse. Several classes of such drugs, including morphine, will increase dopamine release, primarily in… (More)

Determination of dopamine concentrations in brain extracellular fluid using microdialysis with short sampling intervals, analyzed by ultra high performance liquid chromatography tandem mass…

• André Gottås, Åse Ripel, Fernando Boix, Vigdis Vindenes, Jørg G Mørland, Elisabeth Leere Øiestad
• Journal of pharmacological and toxicological…
• 2015

INTRODUCTION An increase in striatal dopamine is considered essential for the rewarding and reinforcing effects of drugs of abuse. We have developed and validated an ultra high performance liquid… (More)

Pharmacokinetics of heroin and its metabolites in vitreous humor and blood in a living pig model

• André Gottås, Marianne Arnestad, Per Steinar Halvorsen, Liliana C. Bachs, Gudrun Høiseth
• Forensic Toxicology
• 2016

Vitreous humor (VH) is an alternative matrix for drug analysis in forensic toxicology. However, little is known about the distribution of xenobiotics, such as opioids, into VH in living organisms.… (More)

Role of 6-monoacetylmorphine in the acute release of striatal dopamine induced by intravenous heroin.

• André Gottås, Fernando Boix, Elisabeth Leere Øiestad, Vigdis Vindenes, Jørg G Mørland
• The international journal of…
• 2014

After injection, heroin is rapidly metabolized to 6-monoacetylmorphine (6-MAM) and further to morphine. As morphine has been shown to increase striatal dopamine, whereas 6-MAM has not been studied in… (More)

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