André Garon

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We report our experience on rituximab-cyclophosphamide-dexamethasone (RCD) combination therapy for the treatment of autoimmune disorders (AIDs) in 48 chronic lymphocytic leukemia (CLL) patients. Overall, 81% of patients were relapsing for AID after previous treatment with corticosteroids, splenectomy, rituximab or alemtuzumab. Diagnosis of AID was(More)
The in vivo implantation of a mechanical device contributes to hemodynamic disturbances, which are responsible for damage to the membranes of red blood cells that in turn can lead to their rupture (hemolysis). It is important to ascertain at the design stage of such mechanical devices that they are innocuous to blood. Because there is no in vivo hemolysis(More)
This study was designed to further our understanding of the elastic ultrastructure of vessels. Scanning electron microscopy and transmission electron microscopy were used to study the histomorphologic properties of the elastic fibers of rabbit aorta after purification of the elastin by means of hot alkaline treatments. The elastic fibers of whole rabbit(More)
Stents are used in interventional cardiology to keep a diseased vessel open. New stents are coated with a medicinal agent to prevent early reclosure due to the proliferation of smooth muscle cells. It is recognized that it is the dose of the agent that effectively controls the cells in the wall of the vessel. This paper focuses on the effect of the number(More)
Stents are used in interventional cardiology to keep a diseased vessel open. New stents are coated with a medicinal agent to prevent early reclosure due to the proliferation of smooth muscle cells. It is the dose of the agent which effectively acts on the cells in the wall of the vessel. This paper gives mathematical models of the dose for a periodic stent(More)
In a previous communication, we have proposed a numerical framework for the prediction of in vitro hemolysis indices in the preselection and optimization of medical devices. This numerical methodology is based on a novel interpretation of Giersiepen-Wurzinger blood damage correlation as a volume integration of a damage function over the computational(More)
The effectiveness of substance delivery through catheters is an important issue in interventional radiology, especially for infusion therapies where the pharmacokinetic advantage of local intra-arterial drug administration has been firmly established. In principle, the procedure is used to provide appropriate local concentrations while maintaining low(More)
The notion of dose that comes from the biologists has been introduced by Delfour et al. (2005 SIAM J. Appl. Math. 65(3):858-881) in the context of coated stents to control restenosis. Assuming a stationary velocity profile of the blood flow in the lumen, it leads to a time-independent equation for the dose that considerably simplifies the analysis and the(More)