André F. van der Merwe

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Catheter-associated bacteriuria (CAB) with transurethral catheters is almost inevitable. Suprapubic catheters (SPCs) are widely considered to decrease the risk of CAB. However, SPCs are implants similarly prone to microbial biofilm formation. The spectrum of colonising pathogens has not been investigated. The aim of this prospective study was: (1) to assess(More)
Urokinase plasminogen activator (uPA) and its inhibitor type 1 (PAI-1) are associated with tumour metabolism and are widely considered to be informative for the identification of cancer. We have analysed prostate tissue resections from patients with prostate cancer (PCa) and with benign prostatic hyperplasia (BPH) for protein levels of uPA and PAI-1, and(More)
Microbial ureteral stent colonisation (MUSC) is one leading risk factor for complications associated with ureteral stent placement. As MUSC remains frequently undetected by standard urine cultures, its definitive diagnosis depends on microbiological investigation of the stent. However, a standard reference laboratory technique for studying MUSC is still(More)
Isothermal microcalorimetry (IMC) has recently been reported as a new method to rapidly detect urinary tract pathogens (UTP). However, further application of microcalorimetry in the clinical setting requires a standardized procedure. An important step toward such standardization is to use a reproducible growth medium. In this study, we investigated the(More)
The use of highly active antiretroviral therapy (HAART) in HIV-infected people has led to a dramatic decrease in the incidence of opportunistic infections and virus-related malignancies such as non-Hodgkin lymphoma and Kaposi sarcoma, but not cervical or anal cancer. Advanced-stage cervical cancer is associated with a high incidence of urological(More)
1. Musser, J. E. et al. Bladder biopsy of normal-appearing mucosa is not helpful in patients with unexplained positive cytology after non-muscle invasive bladder cancer. J. Urol. j.juro.2014.06.068. 2. Jones, J. S. & Larchian, W. A. in CampbellWalsh Urology 10th edn Ch. 81 (eds Wein, A., Kavoussi, L. R., Novick, A. C., Partin, A.(More)
We performed a successful penis allotransplantation on 11 December 2014. Sharing the lessons learned might help more patients in need to be treated this way. We divided the project into manageable segments that was each overseen by an expert. The ethical review and conduct paved the way for a publically acceptable and successful project. Screening for a(More)
Manufacturers worldwide have shifted from the traditional mass production strategy to a more customer friendly and flexible make per order strategy. Competition is no longer limited to product quality and price only, but also encompasses delivery, product differentiation and great services. Due to globalisation manufacturing companies in South Africa are(More)
Raw material inventory is a major element of the working capital of many organizations. Hence its proper control is crucial for the profitability of the organization and development of surrounding communities. The sudden unavailability of raw material inventory for production can be a great operational disturbance which results in delivery delays, customer(More)
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