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BACKGROUND No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. METHODS In this multicenter,(More)
Liver transplantation is currently an accepted first-line treatment for patients with end-stage acute or chronic liver disease, but postoperative complications may limit the long-term success of transplantation. The most common and most clinically significant complications are arterial and venous thrombosis and stenosis, biliary disorders, fluid(More)
Thrombocytopenia (platelet count < 80,000/mm3) in patients with chronic hepatitis has been associated with two factors: the first is hypersplenism resulting from splenomegaly in portal hypertension [1]. The spleen continuously sequesters one-third of circulating platelets, so that splenomegaly increases the fraction of platelets trapped in the splenic(More)
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