André B. P. van Kuilenburg

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Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it is suggested that patients with a partial deficiency of this enzyme are(More)
The effect of the CTP synthetase inhibitor cyclopentenyl cytosine (CPEC) on the metabolism and cytotoxicity of 2′,2′-difluorodeoxycytidine (dFdC, gemcitabine) and the expression and activity of(More)