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Propolis - based chitosan varnish: drug delivery, controlled release and antimicrobial activity against oral pathogen bacteria
BackgroundDental caries is the most prevalent oral disease in several Asian and Latin American countries. It is an infectious disease and different types of bacteria are involved in the process.Expand
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Antileishmanial activity and cytotoxicity of Brazilian plants.
Leishmaniasis is a major public health problem, and the alarming spread of parasite resistance has increased the importance of discovering new therapeutic products. The present study aimed toExpand
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In vitro release and characterization of chitosan films as dexamethasone carrier.
Chitosan, a biodegradable and biocompatible polysaccharide, is a potentially useful material in various fields. We produced mono and bilayer chitosan films containing dexamethasone as a drug carrierExpand
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Poloxamer 407 (Pluronic(®) F127)-based polymeric micelles for amphotericin B: In vitro biological activity, toxicity and in vivo therapeutic efficacy against murine tegumentary leishmaniasis.
In the present study, a Poloxamer 407-based amphotericin B (AmpB)-containing polymeric micelles system (AmpB/M) was employed in the treatment of Leishmania amazonensis-infected BALB/c mice.Expand
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New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment.
Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization. It is a life-threatening disease of medical, social and economic importance in endemic areas. NoExpand
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Novel targeting using nanoparticles: an approach to the development of an effective anti-leishmanial drug-delivery system
The study reported here aimed to develop an optimized nanoparticle delivery system for amphotericin B (AmpB) using a polyelectrolyte complexation technique. For this, two oppositely charged polymersExpand
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An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis
Amphotericin B (AmpB) is active against leishmaniasis, but its use is hampered due to its high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB (NQC-AmpB),Expand
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Antileishmanial activity of standardized fractions of Stryphnodendron obovatum (Barbatimão) extract and constituent compounds.
ETHNOPHARMACOLOGICAL RELEVANCE Stryphnodendron obovatum Benth. is a Brazilian tree used to treat skin ulceration, promote wound healing, and inhibit the growth of protozoa, including Trypanosoma andExpand
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Antileishmanial activity and mechanism of action from a purified fraction of Zingiber officinalis Roscoe against Leishmania amazonensis.
In recent years, considerable attention has been given to identify new antileishmanial products derived from medicinal plants, although, to date, no new effective compound has been recently appliedExpand
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New mesalamine polymeric conjugate for controlled release: Preparation, characterization and biodistribution study
ABSTRACT Mesalamine (5‐ASA) consists of the first‐line therapy for the treatment of ulcerative colitis; however, it has low bioavailability, can cause several systemic adverse events, and has lowExpand
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