András Guseo

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Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated and demyelinated tissue. The reason for concentric demyelination in this variant of multiple sclerosis is unclear. In the present study we investigated the immunopathology in autopsy tissue of 14 patients with acute multiple sclerosis or fulminant exacerbations of(More)
143 autopsy cases of multiple sclerosis (19 acute and 124 chronic cases) were analysed histologically for the extent of active demyelination and the degree of infiltration within and outside the demyelinating lesions and in the leptomeninges. The results were compared with the duration of the illness. Infiltrations were found in 60% of all cases but more(More)
BACKGROUND Proteolytic enzymes such as bromelain and trypsin are used as an adjuvant therapeutic approach in the treatment of chronic inflammatory, malignant and autoimmune diseases. In vitro studies have shown that proteolytic enzymes modulate surface adhesion molecules on T-cells. In this study we analysed the influence of bromelain and trypsin on the(More)
6 autopsy cases of primary leptomeningeal sarcomatosis are presented as a distinct nosological entity with a variable clinical picture and morphology in 5 males and 1 female. The clinical course from onset of symptoms till death ran for only a few weeks in most cases. 2 infants showed brain tumor symptoms and signs, 2 patients of advanced age presented a(More)
Some Hungarian Gypsy communities still live in social isolation with conserved immunogenetical singularities such as a lack of HLA-B7 and high occurrence of HLADR2 (56% in Gypsies vs 21% in Hungarians; Gy6di et al. 1982). The association between multiple sclerosis (MS) and HLA-DR2 in Caucasians is a generally accepted observation (Svejgaard et al. 1983).(More)
In this study, we analysed the recall antigen-induced cytokine production by peripheral blood mononuclear cells (PBMC) from 31 patients with multiple sclerosis (MS) with a relapsing-remitting (rr) and a relapsing-progressive (rp) course and from 40 healthy controls. Cells were stimulated with purified protein derivative (PPD; type 1 response) and tetanus(More)
In a woman, aged 52, who had impaired phosphate excretion and low serum calcium levels, abundant calcium deposits (Pseudokalk) were found between the basement membranes of blood vessels in the regions of corpus striatum and nucleus dentatus as well as in the subcortical white matter and centrum semiovale. Calcium deposits were found also outside blood(More)
In a woman, aged 52, who had impaired phosphate excretion and low serum calcium levels, abundant calcium deposits (Pseudokalk) were found between the basement membranes of blood vessels in the regions of corpus striatum and nucleus dentatus as well as in the subcortical white matter and centrum semiovale. Calcium deposits were found also outside blood(More)
The ultrastructure of calcareous deposits in a case of Sturge-Weber disease is described. Concrements were found mainly extracellularly, outside of blood vessels, but there were some also within the vessel walls. The laminated concrements are built up of fine filaments, similar to those seen in the Fahr's disease. Needle-like cristals (calcium apatit) were(More)