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Probing Solvent Accessibility of Transthyretin Amyloid by Solution NMR Spectroscopy*
The human plasma protein transthyretin (TTR) may form fibrillar protein deposits that are associated with both inherited and idiopathic amyloidosis. The present study utilizes solution nuclearExpand
The Solvent Protection of Alzheimer Amyloid-β-(1–42) Fibrils as Determined by Solution NMR Spectroscopy*
TLDR
These findings provide a molecular explanation for the increased amyloidogenicity and toxicity of Aβ-(1–42) compared with shorter Aβ variants found in vivo, and suggest that the additional residues in Aβ-1-42, Ile41 and Ala42, significantly increase the solvent protection and stability of the C-terminal region Lys28-Ala42. Expand
NMR-based metabolite profiling of human milk: A pilot study of methods for investigating compositional changes during lactation.
TLDR
The results indicate that there are significant compositional changes of the human milk metabolome also in different phases of the matured lactation stage, providing a better understanding of the nutritional variations received by an infant. Expand
Structural Features of Glycosyltransferases Synthesizing Major Bilayer and Nonbilayer-prone Membrane Lipids inAcholeplasma laidlawii and Streptococcus pneumoniae * 210
TLDR
It is proposed that the varying abilities to bind, and sense lipid charge and curvature stress, are governed by typical differences in charge, amphiphilicity, and hydrophobicity for the N- and (catalytic) C-domains of these structurally similar membrane-associated enzymes. Expand
The N-terminal region of amyloid β controls the aggregation rate and fibril stability at low pH through a gain of function mechanism.
TLDR
The results present a possible route for amyloid formation at very low Aβ concentrations and raise the question of whether amyloids formation in vivo is restricted to a low pH environment, and have general implications for the development of therapeutic interventions. Expand
Tryptophan Residues Promote Membrane Association for a Plant Lipid Glycosyltransferase Involved in Phosphate Stress*
TLDR
A model for bilayer “control” of enzyme activity, where two tryptophan segments act as interface anchor points to keep the substrate region close to the membrane surface is proposed. Expand
NMR structure of the ribosomal protein L23 from Thermus thermophilus
TLDR
The solution structure of L23, a component of the large ribosomal subunit in which it is located close to the peptide exit tunnel, is determined from Thermus thermophilus and the observed topology is distantly related to previously known structures. Expand
Metabolite quantification by NMR and LC‐MS/MS reveals differences between unstimulated, stimulated, and pure parotid saliva
TLDR
The combined use of the two metabolomics platforms (NMR and LC‐MS/MS) proved to be viable for research and clinical studies of the salivary metabolome and together extend the metabolome coverage with robust NMR quantification of soluble metabolites and sensitive targeted LC‐ MS/MS analysis of bioactive lipids in specific metabolic pathways. Expand
The HD-exchange motions of ribosomal protein S6 are insensitive to reversal of the protein-folding pathway
TLDR
This study demonstrates that the dynamic motions of the ribosomal protein S6 structure are independent of how the protein folds, and provides a simple rationale for how to interpret native-state dynamics without the need to invoke fluctuations off the normal unfolding reaction coordinate. Expand
NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects
TLDR
The results for the ALS patients suggest an affected creatine/creatinine pathway and an altered branched chain amino acid (BCAA) metabolism, and suggest links to glucose and energy metabolism. Expand
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