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In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefore, we used functional MRI to map(More)
PURPOSE To assess the feasibility to use dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) as an imaging-based liver function test, and to compare two methods for deconvolutional analysis (DA) in healthy human subjects. MATERIALS AND METHODS T(1)-weighted DHCE-MRI with the hepatocyte-specific contrast medium Gd-EOB-DTPA was performed in 20(More)
PURPOSE To evaluate dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) for the assessment of global and segmental liver volume and function in patients with primary sclerosing cholangitis (PSC), and to explore the heterogeneous distribution of liver function in this patient group. MATERIALS AND METHODS Twelve patients with primary sclerosing(More)
OBJECTIVES Gd-EOB-DTPA (gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid) is a gadolinium-based hepatocyte-specific contrast agent for magnetic resonance imaging (MRI). The aim of this study was to determine whether the hepatic uptake and excretion of Gd-EOB-DTPA differ between patients with primary biliary cirrhosis (PBC) and healthy controls,(More)
A novel magnetic resonance imaging approach, called diffusion-direction-dependent imaging (DDI), is introduced. Due to inherent anisotropic diffusion properties, peripheral nerves can be visualized on diffusion tensor imaging (DTI). The largest signal attenuation on DTI correlates with the direction of a nerve fiber, and the least signal attenuation(More)
OBJECTIVES To investigate the influence of 2 different doses and injection rates on the enhancement of liver vasculature in Gd-EOB-DTPA enhanced liver MRI compared with the standard dose Gd-DTPA. MATERIALS AND METHODS This animal experimental study has been approved by the local authorities. In 5 pigs, a time-resolved T1w 3D GRE sequence, and in a second(More)
We examined if MR diffusion tensor imaging with fiber tracking could be performed on the sciatic nerve. In 3 healthy volunteers the proximal thigh was examined on a 1.5-Tesla MR-scanner with a 2-channel phased-array coil. Though inherently susceptible to motion, field inhomogeneities, and fast T(2)-relaxation of the diffusion imaging technique, the sciatic(More)
The k-space readout of propeller-type sequences may be accelerated by the use of parallel imaging (PI). For PROPELLER, the main benefits are reduced blurring due to T(2) decay and specific absorption ratio (SAR) reduction, whereas, for EPI-based propeller acquisitions, such as Turbo-PROP and short-axis readout propeller EPI (SAP-EPI), the faster k-space(More)
Ventriculomegaly at term age is an important predictor of neurologic outcome in preterm infants. Previous studies have found only poor correlations between two-dimensional (2D) cranial ultrasound (US) measurements of lateral ventricles and volume measurements using three-dimensional (3D) magnetic resonance imaging (MRI). Paired cranial MRI and US scans in a(More)
BACKGROUND Magnetic resonance imaging (MRI) is today the imaging modality of choice to investigate the neonatal brain. However, the acoustic noise during scanning is very loud, often exceeding 100 dBA. AIM To reduce the acoustic noise during MRI for neonatal patients. If effective, this would create a safer environment and also result in fewer aborted(More)