Anders Holmström

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Whether desflurane and sevoflurane have clinical advantages over isoflurane in neuroanesthesia is much debated. A porcine model was used for comparison of desflurane and sevoflurane with isoflurane with respect to their cerebrovascular effects. The minimal alveolar concentration (MAC) of each of the three agents was first determined in a standardized manner(More)
Desflurane and sevoflurane may have advantages over isoflurane in neuroanesthesia, but this is still under debate. A porcine model with experimental intracranial hypertension was used for paired comparison of desflurane, sevoflurane, and isoflurane with respect to the effects on cerebral blood flow (CBF), cerebrovascular resistance (CVR), and intracranial(More)
Algorithms for derivative free optimization are overviewed, summarized and examined. Among the methods studied are Quasi Newton methods, the Nelder Mead Simplex algorithm, the Multidirectional search algorithm, Trust-region methods, the Response surface methodology and Model based optimization. A best and worst choice has been indicated for problems with(More)
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