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In 1972--1973, 785 symptom-free men, aged 40 to 49 years, without target organ damage, with systolic blood pressures between 150 and 179 mm Hg and diastolic blood pressure below 110 mm Hg, were assigned at random to one of two groups: (406 to a drug treatment group and 379 to a control group) for a five-year controlled drug treatment trial to evaluate the(More)
Line integral convolution (LIC) is a powerful texture-based technique for visualizing vector fields. Due to the high computational expense of generating 3D textures and the difficulties of effectively displaying the result, LIC has most commonly been used to depict vector fields in 2D or over a surface in 3D. We propose new methods for more effective volume(More)
Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension. The results come from 300 men after three years of follow up; 150 men in the treatment group and 150 men in the control group. The treatment has been standardized starting with hydrochlorothiazide(More)
1 The report presents the effects on blood lipids and uric acid of six different antihypertensive drugs, used alone and of five different combinations of two antihypertensive drugs. 2 Prazosin significantly lowered serum LDL + VLDL cholesterol and total triglycerides. Atenolol lowered LDL + VLDL cholesterol to a smaller but significant extent. Both pindolol(More)
In 20 middle-aged men with untreated sustained essential hypertension for more than 5 years, both plasma adrenaline and noradrenaline were positively and significantly correlated with blood pressure. In both hypertensives and 19 normotensive control subjects supine arterial adrenaline concentrations were more than twice the venous concentrations consistent(More)
The high density lipoprotein (HDL) cholesterol concentrations of frozen specimen obtained in 1972-73 are reported from 93 men aged 40-49 years who later developed coronary heart disease (CHD), and for 186 controls. Mean HDL cholesterol of CHD-patients was 7.9% lower than that of controls matched for smoking habits and serum concentrations of triglycerides(More)
Enalapril, atenolol, and hydrochlorothiazide were compared in a double-blind randomised parallel study in general practice. 436 patients with mild to moderate hypertension were included at 76 centres. A two-week placebo run-in period was followed by 16 weeks of monotherapy. The initial doses were: enalapril 20 mg; atenolol 50 mg; and hydrochlorothiazide 25(More)
In 1972-1973, about 16,200 men living in Oslo, aged 40 to 49 years, were examined for cardiovascular disease, and had a number of coronary risk factors measured. This report gives the results of 129 autopsied cases with regard to the association between raised atherosclerotic lesions in coronary and cerebral arteries and various coronary risk factors. For(More)
In 23 hypertensive men, aged 47-55, propranolol reduced serum high-density-lipoprotein (HDL) cholesterol by 13% reduced the ratio of HDL to low-density-lipoprotein (LDL)+very-low-density-lipoprotein (VLDL) cholesterol by 15%, increased total triglycerides by 24%, and increased serum uric acid by 10%. Prazosin reduced total serum cholesterol by 9%, LDL+VLDL(More)