To better understand the evolution of a key metabolic pathway, we have sequenced the trpCFBA gene cluster of the hyperthermophilic bacterium Thermotoga maritima. The genes were cloned by… (More)
Combined oral contraceptives and combined oral postmenopausal hormone therapy are associated with a weak, but clinically significant risk of arterial and venous thrombosis (VT). The effects are… (More)
BACKGROUND
Postmenopausal hormone therapy is associated with many diseases and conditions, e.g., cardiovascular diseases and asthma, but the underlying molecular mechanisms are incompletely… (More)
UNLABELLED
ESSENTIALS: A hypoxic microenvironment is a common feature of tumors that may influence activation of coagulation. MCF-7 and SK-BR-3 breast cancer cells and breast cancer tissue samples… (More)
The role of the extra helix alpha zero in the N-terminal extension of the eight-fold beta alpha barrel of indoleglycerol phosphate synthase was probed by point mutation and truncation. Replacing… (More)
Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress… (More)
Tissue factor (TF) pathway inhibitor I (TFPI) is the physiological inhibitor of TF-induced blood coagulation. Circulating blood contains full-length TFPI and TFPI truncated at the C-terminal end.… (More)
Study design:This is a double-blind, randomized, placebo-controlled cross-over study of melatonin in complete tetraplegia.Objectives:Tetraplegic patients have an increased risk of venous thrombosis… (More)