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BACKGROUND AND PURPOSE Low-level laser therapy (LLLT) modulates various biological processes. In the present study, we assessed the hypothesis that LLLT after induction of stroke may have a beneficial effect on ischemic brain tissue. METHODS Two sets of experiments were performed. Stroke was induced in rats by (1) permanent occlusion of the middle(More)
OBJECTIVES/AIMS The study was designed to evaluate the optimal dosage of lamotrigine, as monotherapy, in the treatment of adults suffering from complex partial seizures with or without secondary generalization in everyday clinical practice. MATERIALS AND METHODS The ones used in this study was the collection of the data of all adult patients treated with(More)
Pathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathological laughter after midbrain and pontine-midbrain infarction.(More)
Stroke is a well-known cause for seizures in the adult population. Research in animal models indicates that abnormalities in the blood–brain barrier (BBB) permeability can play a role in the development of spontaneous seizures or status epilepticus. The integrity of the BBB was investigated in patients with late post-stroke seizures by performing DTPA-SPECT(More)
Traumatic brain injury (TBI) is a major cause of seizures in the general population. Several studies have shown an increased risk of epilepsy after traumatic brain injury, depending on risk factors, such as severity and time post trauma. The aim of our study was to evaluate the appearance of late seizures after a very mild head trauma or whiplash injury.(More)
BACKGROUND AND PURPOSE Previous overt stroke and subclinical stroke are frequent in patients with stroke; yet, their clinical significance and effects on stroke outcome are not clear. We studied the burden and outcome after acute ischemic stroke by prevalent ischemic brain disease in a national registry of hospitalized patients with acute stroke. METHODS(More)
lateral and were never accompanied or preceded by painful or unpleasant sensation. Medical history was remarkable for breast cancer at the age of 45, with no adjuvant treatment, such as chemotherapy or radiotherapy. The patient also had bilateral hip replacement at the age of 40, bilateral cataract surgery at the age of 60 and transurethral prostatectomy(More)
Mutations or structural genomic alterations of the X-chromosomal gene ARHGEF9 have been described in male and female patients with intellectual disability. Hyperekplexia and epilepsy were observed to a variable degree, but incompletely described. Here, we expand the phenotypic spectrum of ARHGEF9 by describing a large Ethiopian-Jewish family with epilepsy(More)
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