Anchal Sharma

Learn More
PURPOSE Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHODS Genome-wide analysis of CNVs > 100(More)
INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus encodes three tumor suppressor genes namely CDKN2A, ARF, CDKN2B and a long non-coding RNA CDKN2B-AS1 (also(More)
The limited performance of voltage mode Op-amps such as bandwidth, slew-rate etc. led the analog designer to search for other possibilities and other building blocks. Thus the current-mode active building blocks received considerable attention due to their larger dynamic range, high frequency, lower power consumption, high slew rate, better linearity,(More)
Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally. The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely influenced by the rate of aqueous humor production by ciliary processes and its passage through the trabecular meshwork(More)
Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base variations measuring up to 0.48% of the total variations. Interestingly, about 64% of these somatic variations in(More)
— Morse Code is an efficient tool for communicating with the disabled people especially those with speech impairments and a variety of neuromuscular diseases like multiple sclerosis and muscular dystrophy. It is quite difficult to implement morse code with people having severe physical restriction as in the severe cases of Cerebral Palsy. This paper aims at(More)
  • 1